Patent · US Active

Monomethylvaline compounds capable of conjugation to ligands

US10808039B2 · kind B2 · utility

9Cited by

86References

10Claims

0Family size

Assignee

SEATTLE GENETICS, INC. · US

Inventors

Svetlana O. Doronina · Snohomish, US
Peter D. Senter · Seattle, US
Brian E. Toki · Shoreline, US
Toni Kline · Seattle, US

Key dates

Filing date	Jul 10, 2019
Grant date	Oct 20, 2020
Priority date	—
Expiry date	Jul 10, 2039

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY10T428/13
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Auristatin peptides, including MeVal-Val-Dil-Dap-Norephedrine (MMAE) and MeVal-Val-Dil-Dap-Phe (MMAF), were prepared and attached to Ligands through various linkers, including maleimidocaproyl-val-cit-PAB. The resulting ligand drug conjugates were active in vitro and in vivo.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.