Ultrasound system for shearing cellular material in a microplate

US10809166B2 · kind B2 · utility

Assignees

• Matchstick Technologies, Inc. · US
• University of Washington · US

Inventors

• Karol Bomsztyk · Mercer Island, US
• Greg P. Darlington · Snohomish, US
• Brian MacConaghy · Kent, US
• Thomas J. Matula · Kirkland, US
• Adam D. Maxwell · Seattle, US

Key dates

• Filing date: Jan 17, 2018
• Grant date: Oct 20, 2020
• Expiry date: Nov 4, 2038

Classification

• Technology area (CPC H): Electricity
• CPC primary: H10N30/03
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Disclosed embodiments include illustrative piezoelectric element array assemblies, methods of fabricating a piezoelectric element array assembly, and systems and methods for shearing cellular material. Given by way of non-limiting example, an illustrative piezoelectric element array assembly includes at least one piezoelectric element configured to produce ultrasound energy responsive to amplified driving pulses. A lens layer is bonded to the at least one piezoelectric element. The lens layer has a plurality of lenses formed therein that are configured to focus ultrasound energy created by single ones of the at least one piezoelectric element into a plurality of wells of a microplate disposable in ultrasonic communication with the lens layer, wherein more than one of the plurality of lenses overlie single ones of the at least one piezoelectric element.