Non-invasive hemodynamic assessment via interrogation of biological tissue using a coherent light source

US10813597B2 · kind B2 · utility

Assignees

• The Regents of the University of California · US
• Covidien LP · US

Inventors

• Tyler Bywaters Rice · Santa Ana, US
• Michael Ghijsen · Irvine, US
• Bruce J. Tromberg · Irvine, US
• Bruce Yee Yang · Irvine, US
• Sean Michael White · Los Angeles, US

Key dates

• Filing date: Apr 14, 2017
• Grant date: Oct 27, 2020
• Expiry date: Sep 23, 2038

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61B5/726
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

Systems and methods are disclosed for determining physiological information in a subject. The system includes: a light source positionable along a first location outside of the subject; a photo-sensitive detector positionable along a second location outside of the subject and configured to detect scattered light and generate a signal; a processor having a program and a memory, wherein the processor is operably coupled to the detector and configured to receive and store the signals generated over a period of time; wherein the processor is programmed to derive contrast metrics from the stored signals, calculate a waveform from the contrast metrics, decompose the waveform into basis functions and respective amplitudes, and compare the basis function amplitudes to determine the physiological information.