Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
US10814013B2 · kind B2 · utility
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12Claims
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Key dates
| Filing date | Jul 31, 2012 |
| Grant date | Oct 27, 2020 |
| Priority date | — |
| Expiry date | Dec 3, 2032 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P35/02
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.
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