Targeted delivery of molecules using impedance-based monitoring at elevated temperatures
US10814129B1 · kind B1 · utility
Assignees
Inventors
Key dates
| Filing date | Mar 9, 2020 |
| Grant date | Oct 27, 2020 |
| Priority date | — |
| Expiry date | Mar 9, 2040 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61N2005/0652
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
A method and system for delivering a molecule to a specific area of a tissue by controlling temperature and impedance is presented. The method is generally comprised of applying heat to a biological structure, such as cells or tissues, to heat the biological structure to a preset temperature after which at least one electroporation pulse is administered to the biological structure. Impedance is measured as a feedback control mechanism after each pulse and pulse parameters are adjusted accordingly until desired impedance is reached. The system generally comprises an electroporation system capable of generating at least one pulse, measuring impedance and measuring temperature.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.