(S)-CSA salt of S-ketamine, (R)-CSA salt of S-ketamine and processes for the preparation of S-ketamine

US10815196B2 · kind B2 · utility

Assignee

• Janssen Pharmaceuticals, Inc. · BE

Inventors

• Cheng-Yi Chen · Burnaby, CA
• Oliver Floegel · Zürich, CH
• Michael Justus · Beloit, US
• Adrian Maurer · Schaffhausen, CH
• Karl Reuter · Gundelfingen, DE
• Tobias Strittmatter · Schaffhausen, CH
• Tobias Wedel · Karlsruhe, DE

Key dates

• Filing date: Jun 4, 2018
• Grant date: Oct 27, 2020
• Expiry date: Jun 4, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2602/42
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention is directed to processes for the preparation of esketamine. The present invention is further directed to processes for the resolution of S-ketamine from a racemic or enantiomerically enriched mixture of ketamine. The present invention is further directed to an (S)-CSA salt of S-ketamine, more particularly a monohydrate form of the (S)-CSA salt of S-ketamine; and to an (R)-CSA salt of R-ketamine.