Salts, crystal forms, and production methods thereof

US10815249B2 · kind B2 · utility

Assignee

• Sunovion Pharmaceuticals Inc. · US

Inventors

• Andrea Bauer · North Reading, US
• Xiaoxia Chen · Beijing, CN
• Shahla Jamzad · Belmont, US
• Robert Joseph PRYTKO · Millbury, US
• Michael J. Sizensky · Grafton, US
• Haitao Zhang · Ithaca, US

Key dates

• Filing date: Feb 15, 2019
• Grant date: Oct 27, 2020
• Expiry date: Feb 15, 2039

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/13
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided are salts of (S)-(4,5-dihydro-7H-thieno[2,3-c]pyran-7-yl)-N-methylmethanamine and various of crystal forms thereof, and compositions, medicaments, pharmaceutically acceptable formulations thereof, and methods of making same. In addition, provided are compounds comprising specific particle size distributions of crystalline (S)-(4,5-dihydro-7H-thieno[2,3-c]pyran-7-yl)-N-methylmethanamine HCl and methods of making and modulating the particle size distributions.