Patent · US Active

Three-dimensional differentiation of epiblast spheroids to kidney organoids models stage-specific epithelial physiology, morphogenesis, and disease

US10815460B2 · kind B2 · utility

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Assignee

Inventors

Key dates

Filing dateSep 2, 2016
Grant dateOct 27, 2020
Priority date—
Expiry dateSep 2, 2036

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC12N2506/45
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

Human pluripotent stem cells (hPSCs) have dual value as microphysiological laboratory models and regenerative therapeutics. hPSCs are epithelial cells, but the extent to which hPSCs and descendant epithelia can reconstitute lineage-specific functions remains poorly understood. Here the Inventors show that hPSCs in three-dimensional cultures and their differentiated descendants can functionally recapitulate tissue-specific epithelial morphogenesis, physiology, and disease.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.