Patent · US Active

Chemically modified AMPA receptor RNA aptamers

US10815486B2 · kind B2 · utility

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1References

16Claims

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Assignee

The Research Foundation for The State University of New York · US

Inventors

Li Niu · Loudonville, US
Zhen Huang · Brooklyn, US

Key dates

Filing date	Jul 5, 2018
Grant date	Oct 27, 2020
Priority date	—
Expiry date	Jul 22, 2038

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2310/322
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Disclosed is an RNA aptamer, a synthetic oligonucleotide of 2′-fluoro-modified A, U, and C nucleotides, with improved stability compared to its unmodified counterpart. Like the unmodified aptamer, however, the modified version is a potent glutamate receptor antagonist. Additionally, the RNA aptamers described herein are water soluble by nature, and generally exhibit nano- to micromolar potency making them potential therapeutic agents for the treatment of neurological disorders involving glutamate receptor activity.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.