Method for establishing resistance characteristics of a biological indicator
US10815516B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | Dec 1, 2015 |
| Grant date | Oct 27, 2020 |
| Priority date | — |
| Expiry date | Dec 30, 2035 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q1/22
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A method is provided for establishing resistance characteristics of a biological indicator in a sterilization process using a sterilant vapor. The method includes the step of creating a biological indicator inactivation profile by obtaining differential sterilant vapor pressure values in a sterilization chamber during sterilant vapor injection and determining D-values as a function of the differential sterilant vapor pressure values obtained. The biological indicator inactivation profile, when represented as a function of differential sterilant vapor pressure, may be linear over the full range of inactivation. The biological indicator inactivation profile may be created by injecting the sterilant vapor into the sterilization chamber and measuring biological indicator survival at different differential sterilant vapor pressure values. The method may include providing biological indicator inactivation data during sterilization at a given sterilization chamber temperature and initial sterilant concentration for use in creating the biological indicator inactivation profile at another temperature and sterilant concentration.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.