Process for the production of N-Boc-2-amino-3,3-dimethylbutyric acid
US10822304B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Nov 23, 2017 |
| Grant date | Nov 3, 2020 |
| Priority date | — |
| Expiry date | Nov 23, 2037 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C269/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The current invention offers a process for the production of N-Boc-2-amino-3,3-dimethylbutyric acid by a reaction of tert-Leucine with di-tert-butyl-dicarbonate, the process comprising (i) contacting the tert-Leucine with di-tert-butyl-dicarbonate in an aqueous medium, optionally comprising a first organic solvent, in the presence of an inorganic base, (ii) optionally removing the first organic solvent, (iii) optionally extracting the resulting N-Boc-2-amino-3,3-dimethylbutyric acid into a second organic solvent, (iv) isolating the product by precipitation from the reaction mixture at acidic pH, and (v) optionally reuse the first and/or second organic solvents recovered from step (ii) and/or step (iv) for the next production cycle. The process is sufficiently short, uses preferably environmental friendly solvents, avoids waste and leads to good yields.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.