Cells expressing chimeric activating receptors and chimeric stimulating receptors and uses thereof

US10822413B2 · kind B2 · utility

Assignee

• Eureka Therapeutics, Inc. · US

Inventors

• Hong Liu · Seattle, US
• Pengbo Zhang · Fremont, US
• Lucas HORAN · Emeryville, US
• Yiyang Xu · Pleasanton, US
• Binnaz K. Staley · San Carlos, US
• Lianxing Liu · San Francisco, US
• Hongruo YUN · Emeryville, US

Key dates

• Filing date: Oct 22, 2019
• Grant date: Nov 3, 2020
• Expiry date: Oct 22, 2039

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/43
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present application provides immune cells (such as T cells) comprising a chimeric antibody-T cell receptor (TCR) construct (caTCR) and a chimeric signaling receptor (CSR) construct. The caTCR comprises an antigen-binding module that specifically binds to a target antigen and a T cell receptor module (TCRM) capable of recruiting at least one TCR-associated signaling molecule, and the CSR comprises a ligand-binding domain that specifically binds to a target ligand and a co-stimulatory signaling domain capable of providing a stimulatory signal to the immune cell. Also provided are methods of making and using these cells.