Masking chimeric antigen receptor T cells for tumor-specific activation
US10822419B2 · kind B2 · utility
1Cited by
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20Claims
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Key dates
| Filing date | Jun 27, 2016 |
| Grant date | Nov 3, 2020 |
| Priority date | — |
| Expiry date | Dec 16, 2036 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention is directed to a masked chimeric antigen receptor, comprising: (a) a masking peptide; (b) one or more antigen-specific targeting domains; (c) an extracellular spacer domain; (d) a transmembrane domain; (e) at least one co-stimulatory domain; and (f) an intracellular signaling domain. The mCARs are activated upon cleavage of the masking peptide.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.