Method of assessing disease condition of cancer

US10823736B2 · kind B2 · utility

Assignees

• The Regents of the University of California · US
• Cedars Sinai Medical Center · US

Inventors

• Hsian-Rong Tseng · Los Angeles, US
• Jiaoti Huang · Los Angeles, US
• Edwin M. Posadas · Los Angeles, US
• Jiefu Chen · Cypress, US
• Hao Ho · Honolulu, US
• Zunfu Ke · Los Angeles, US
• Ker-Chau Li · Los Angeles, US
• Yi-Tsung Lu · Shanghai, CN
• Jake Lichterman · Los Angeles, US
• Min Song · Hwaseong-si, KR
• Leland W.K. Chung · Lovingston, US

Key dates

• Filing date: Sep 28, 2015
• Grant date: Nov 3, 2020
• Expiry date: Jul 22, 2036

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2800/56
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

A method, system and computer-readable medium for assessing a disease condition of a cancer of a subject, including: receiving a blood sample from the subject; isolating a plurality of circulating tumor cells (CTCs) from the blood sample; measuring at least one of cell or cell nucleus sizes of each of the plurality of CTCs; determining a measured CTC size distribution of the plurality of CTCs based on the measuring; comparing the measured CTC size distribution to a reference CTC size distribution using a computer; and assigning the disease condition of the cancer of the subject based on the comparing.