Degradable magnesium-containing calcium phosphate-calcium sulfate porous composite biological scaffold

US10828396B2 · kind B2 · utility

Assignee

• Yaping Li · CN

Inventors

• Yaping Li · Ningbo City, CN
• Sang Li · Ningbo City, CN
• Haijiao Mao · Ningbo City, CN
• Tingting Tang · Ningbo City, CN
• Jun Fu · 魏塘街道, CN
• Hanfeng Xiong · Ningbo City, CN
• Lei Nie · San Diego, US
• Jianmin ZHENG · Ningbo City, CN
• Guofeng Zhang · Ningbo City, CN

Key dates

• Filing date: Jan 4, 2017
• Grant date: Nov 10, 2020
• Expiry date: Jan 4, 2037

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61L2430/40
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

A method for preparing a degradable magnesium-containing calcium phosphate-calcium sulfate porous composite biological scaffold by subjecting a calcined bovine cancellous bone mineral porous scaffold to a treatment using a ternary system containing a magnesium source, a sulfur source and a phosphorus source, taking out and drying, and subjecting to a high-temperature calcination. The degradable magnesium-containing calcium phosphate-calcium sulfate porous composite biological scaffold has good three-dimensional interconnected mesh structure, osteoconductivity, degradability, good mechanical strength and biocompatibility, simultaneously. At the same time, calcium sulfate whiskers with larger length-diameter ratio grow in the mesh, thereby increasing the specific surface area of the material and possibly improve the adhesion of cells. The composite biological scaffold may have potential osteoinductivity due to the effective addition of the osteogenic active ionized magnesium and the calcium sulfate which can produce a local high-calcium environment when degraded.