Naphthoquinones, pro-drugs, and methods of use thereof

US10829427B2 · kind B2 · utility

Assignee

• The Board of Regents of the University of Texas System · US

Inventors

• Jinming Gao · Dallas, US
• Yuliang Liu · New York, US
• Qi Wei · Dallas, US
• Xinpeng MA · Cambridge, US
• Gang Huang · Nanhu, CN

Key dates

• Filing date: Dec 16, 2016
• Grant date: Nov 10, 2020
• Expiry date: Dec 16, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2602/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided herein are naphthoquinones compounds such as those with a hydrogen bond donating group of the formula (I): wherein: R1, R2, R3, R4, R5, and n are as defined herein. Also provided herein are pharmaceutical composition of the present compounds and methods of treatment using the compounds including their use in the treatment of cancer.