Patent · US Active

Methods of resolving racemic mixture to obtain (−)-Huperzine A

US10829455B2 · kind B2 · utility

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17Claims

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Inventors

Yonggang Xu · Nanjing, CN
Hao-Ming Wei · Beijing, CN
Song Chen · Nanhu, CN
Haoning Zhang · Nanjing, CN

Key dates

Filing date	Mar 19, 2019
Grant date	Nov 10, 2020
Priority date	—
Expiry date	Mar 19, 2039

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D471/12
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

A method of resolving a racemic mixture of (±)-Huperzine A to (−)-Huperzine A includes: separating the (−)-Huperzine A from the racemic mixture of (±)-Huperzine A by chiral high performance liquid chromatography (HPLC), the chiral HPLC being performed utilizing a mobile phase including a solution including an alcohol and one selected from dichloromethane, trichloromethane, and a mixture thereof, and the chiral HPLC being performed utilizing a chiral stationary phase including a polysaccharide derivative.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.