Interleukin-2 muteins for the expansion of T-regulatory cells
US10829535B2 · kind B2 · utility
5Cited by
9References
5Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 21, 2018 |
| Grant date | Nov 10, 2020 |
| Priority date | — |
| Expiry date | Feb 21, 2038 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/43
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Provided herein are IL-2 muteins and IL-2 mutein Fc-fusion molecules that preferentially expand and activate T regulatory cells and are amenable to large scale production. Also provided herein are variant human IgG1 Fc molecules lacking or with highly reduced effector function and high stability despite lacking glycosylation at N297. Also, provided herein are linker peptides that are glycosylated when expressed in mammalian cells.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.