Method employing bispecific antibodies
US10829566B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | Dec 1, 2016 |
| Grant date | Nov 10, 2020 |
| Priority date | — |
| Expiry date | Dec 1, 2036 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/00
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention relates to a method of identifying, separating and characterizing a cell or a population of cells, by capturing at the cell surface, secreted soluble substances (such as an immunoglobulin) that cell or population of cell secrete. This is achieved by combing on a heterodimerically-tethered multispecific protein complex combining a binding specificity for the secreted molecule and a binding specificity for a surface antigen specific for that cell or population of cells. This method may be used in research and experimental purposes, such as patients' stratification in preparation of clinical trials or personalized therapies by identifying cell populations relevant to a pathology and/or prognosis.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.