Photo-controlled removal of targets in vitro and in vivo

US10830678B2 · kind B2 · utility

Assignee

• The United States of America, as represented by the Secretary, Department of Health and Human Serv · US

Inventors

• Hisataka Kobayashi · Laurel, US
• Peter Choyke · Rockville, US
• Martin John Schnermann · Rockville, US

Key dates

• Filing date: Aug 7, 2015
• Grant date: Nov 10, 2020
• Expiry date: Sep 10, 2035

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61N2005/0663
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This disclosure provides IR700-molecule conjugates and methods of their use to remove (e.g., separate or isolate) a target from a sample in vivo or from a subject in vitro. It is shown herein that exposure of IR700 to near infrared (NIR) light removes a portion of IR700, changing it from a hydrophilic molecule, to one that is hydrophobic, resulting in aggregation of IR700 and anything bound to it. For example, the disclosed IR700-molecule conjugates and methods provide photo-controlled ways to control the pharmacokinetics of a drug in vivo, and can be used to remove undesired agents from environmental or food samples or to isolate target molecules in a laboratory.