Device for rapid detection of tuberculosis-lipoarabinomannan (TB-LAM) with enhanced sensitivity

US10830760B2 · kind B2 · utility

Assignee

• General Electric Company · US

Inventors

• Matthew Jeremiah Misner · Delanson, US
• Gregory Andrew Grossmann · Halfmoon, US
• Cathryn Ellen Olsen · Ballston Spa, US
• John Richard Nelson · Fryeburg, US
• David Roger Moore · Rexford, US
• Paul Michael Smigelski, Jr. · Schenectady, US
• John Thomas Connelly · Seattle, US
• Benjamin David Grant · Bellevue, US
• Bernhard Weigl · Seattle, US

Key dates

• Filing date: Dec 20, 2017
• Grant date: Nov 10, 2020
• Expiry date: Aug 1, 2038

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2015/1493
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

A device for rapid detection of a tuberculosis lipoarabinomannan (TB-LAM) is provided. The device includes a pre-concentrator unit for concentrating the TB-LAM comprising: an ion-exchange medium comprising one or more ligands configured to capture the TB-LAM from the source biological sample, wherein the captured-TB-LAM is eluted from the ion-exchange medium as an eluate comprising a concentrated form of TB-LAM; a cassette; a lateral flow assay unit disposed in the cassette; and an integration unit attached to the pre-concentrator unit and the cassette. The integration unit is configured to operatively couple and de-couple the pre-concentrator unit and the cassette. The pre-concentrator unit and the lateral flow assay unit disposed in the cassette are in a fluidic communication in a coupled form. The device for rapid detection of TB-LAM further comprises a dilutor unit.