Method for determining the temporal progression of a biological phenomenon and associated methods and devices
US10832089B2 · kind B2 · utility
Assignees
- Institut National de la Sante et de la Recherche Medicale (INSERM)
- INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE
- ECOLE POLYTECHNIQUE
- INRIA—INSTITUT NATIONAL DE RECHERCHE EN INFORMATIQUE ET EN AUTOMATIQUE
- CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
- Sorbonne Universite
- ASSISTANCE PUBLIQUE—HÔPITAUX DE PARIS (APHP)
Inventors
Key dates
| Filing date | May 11, 2016 |
| Grant date | Nov 10, 2020 |
| Priority date | — |
| Expiry date | Aug 26, 2036 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG16H50/30
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
Provided herein is a method for determining the temporal progression of a biological phenomenon which may affect a studied subject, the method including the steps of providing first data relative to biomarkers for the studied subject, the biomarkers being relative to the progression of the biological phenomenon, providing a numerical model, converting the first data into at least one point on the same Riemann manifold, and using a numerical model to determine a temporal progression for the biological phenomenon for the studied subject, the numerical model being a function in a Riemann manifold, the numerical model associating to values of biomarkers a temporal progression trajectory for the biological phenomenon and data relative to the dispersion of the progression trajectory for the biological phenomenon among a plurality of subjects, the numerical model being obtained by using a stochastic approximation in an expectation-maximization technique on data relative to biomarkers.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.