Polyplexes
US10835549B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Apr 11, 2014 |
| Grant date | Nov 17, 2020 |
| Priority date | — |
| Expiry date | Apr 11, 2034 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61L2300/252
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present disclosure relates to compounds comprising (i) an active agent, wherein the active agent includes a charge at a predetermined pH, (ii) a polymer, wherein the polymer includes an opposite charge than the active agent at the predetermined pH; and (iii) a polyplex comprising the peptide and the polymer electrostatically bond together at the predetermined pH. In some embodiments, the active agent is a peptide, such as a peptide comprising MAPKAP kinase II inhibitory peptide, and in some embodiments the peptide includes a cell-penetrating peptide. In further embodiments, the disclosure provides methods for treating a disease or condition by administering a composition according to the present disclosure to a subject in need thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.