Bioconjugates made from recombinant N-glycosylated proteins from procaryotic cells
US10835592B2 · kind B2 · utility
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2References
9Claims
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Assignee
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Key dates
| Filing date | Oct 23, 2014 |
| Grant date | Nov 17, 2020 |
| Priority date | — |
| Expiry date | Oct 23, 2034 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention is directed to a bioconjugate vaccine, such as an O1-bioconjugate vaccine, comprising: a protein carrier comprising a protein carrier containing at least one consensus sequence, D/E-X-N-Z-S/T, wherein X and Z may be any natural amino acid except proline; at least one antigenic polysaccharide from at least one pathogenic bacterium, linked to the protein carrier; and, optionally, an adjuvant. In another aspect, the present invention is directed to a method of producing an O1-bioconjugate in a bioreactor comprising a number steps.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.