Process for the conjugation of a peptide or protein with a reagent comprising a leaving group including a portion of PEG
US10835616B2 · kind B2 · utility
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21Claims
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Key dates
| Filing date | Oct 8, 2015 |
| Grant date | Nov 17, 2020 |
| Priority date | — |
| Expiry date | Oct 7, 2036 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K1/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to novel conjugating reagents capable of reaction with at least one nucleophile present in a peptide or protein, which contain at least one leaving group which is lost on reaction with said nucleophile, in which the leaving group includes a portion —(CH2CH2O)n—, in which n is a number of six or more; and novel processes for the preparation of conjugates containing peptides or proteins made using such reagents.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.