Targeted therapy to repolarize tumor-associated macrophages (TAMs)
US10835619B1 · kind B1 · utility
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11Claims
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Key dates
| Filing date | Aug 15, 2017 |
| Grant date | Nov 17, 2020 |
| Priority date | — |
| Expiry date | Aug 28, 2037 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K47/6851
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Provided herein is a tumor associated macrophage (TAM)-targeting liposome. The liposome has a lipid bilayer, a targeting agent associated with the lipid bilayer, and a repolarizing agent associated with the lipid bilayer. The targeting agent optionally comprises an antibody or fragment thereof that selectively binds a TAM, whereas the repolarizing agent repolarizes the TAM upon binding of the TAM by the targeting agent. Also provided is a pharmaceutical composition comprising the TAM-targeting liposomes and a method of treating a subject with cancer with the compositions or liposomes described herein.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.