Patent · US Active

Fluorinated cyclopropylamine compound, preparation method therefor, pharmaceutical composition thereof, and uses thereof

US10836743B2 · kind B2 · utility

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0References

12Claims

0Family size

Assignee

SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES · CN

Inventors

Hong Liu · Shanghai, CN
Jia-He Li · Cockeysville, US
Jiang Wang · Shanghai, CN
Mingbo Su · Shanghai, CN
Shuni Wang · Shanghai, CN
Yubo Zhou · Shanghai, CN
Wei Zhu · Shanghai, CN
Wei Xu · Saginaw, US
Chunpu Li · Qingdao, CN
Hualiang Jiang · Shanghai, CN
Kaixian Chen · Shanghai, CN

Key dates

Filing date	Mar 16, 2017
Grant date	Nov 17, 2020
Priority date	—
Expiry date	Mar 19, 2037

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY02P20/55
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

Provided is a fluorinated cyclopropylamine compound represented by formula I, a racemate thereof, an R-isomer thereof, an S-isomer thereof, a pharmaceutical salt thereof, and a mixture thereof. Also provided are pharmaceutical compositions containing the compound, a preparation method for the compound, and uses thereof as a lysine specific demethylase 1 (LSD1) inhibitor, and in the treatment of cancers.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.