Molecular imprinted colored silica beads
US10837961B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | Aug 6, 2014 |
| Grant date | Nov 17, 2020 |
| Priority date | — |
| Expiry date | Apr 11, 2037 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2600/00
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Macromolecular imprinted silica particles (“MIP”) in the presence of polymer grafted carbon black are disclosed. The disclosed molecular imprinted beads can detect disease in body fluids. For the silica gel matrix, tetraethyl orthosilicate (TEOS) was used as the backbone monomer and 3-aminopropy/triethoxysilane (APS) as a functional monomer. Carbon black was added to the sol-gel process, yielding black silica particles. Furthermore, sodium dodecyl sulfate (SDS) was used as a structure-directing agent to increase network diffusion of the template. A total of 16 MIPs were synthetized in parallel with variables that evaluate the role of key reactants in the synthesis procedure. Agglomeration tests were performed with all 16 MIPs in the presence of their template, alongside their respective controls using only phosphate buffered saline (“PBS”). Each of the MIPs was evaluated using a novel device capable of simultaneously measuring up to four samples for near infrared transmission.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.