Method and device for high-resolution color imaging using merged images from holographic and lens-based devices

US10838192B2 · kind B2 · utility

Assignee

• The Regents of the University of California · US

Inventors

• Aydogan Ozcan · Los Angeles, US
• Yibo Zhang · Nanhu, CN
• Yichen Wu · Los Angeles, US

Key dates

• Filing date: May 9, 2017
• Grant date: Nov 17, 2020
• Expiry date: Dec 9, 2037

Classification

• Technology area (CPC G): Physics
• CPC primary: G06T2207/20221
• WIPO field: Optics
• WIPO sector: Instruments

Abstract

Methods and systems for generating a high-color-fidelity and high-resolution color image of a sample are disclosed; which fuses or merges a holographic image acquired at a single wavelength with a color-calibrated image taken by a low-magnification lens-based microscope using a wavelet transform based colorization method. A holographic microscope is used to obtain holographic images which are used to computationally reconstruct a high-resolution mono-color holographic image of the sample. A lens-based microscope is used to obtain low resolution color images. A discrete wavelet transform (DWT) is used to generate a final image that merges the low-resolution components from the lens-based color image and the high-resolution components from the high-resolution mono-color holographic image.