Systems and methods for evaluating perturbation of xenobiotic metabolism
US10842444B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Sep 4, 2014 |
| Grant date | Nov 24, 2020 |
| Priority date | — |
| Expiry date | May 22, 2036 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG16B5/00
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
Systems and methods are provided for assessing perturbation of a target biological tissue caused by exposure to an agent. A set of scores indicative of a perturbation of the target biological tissue is determined based on a set of contrast data and a computational causal network model of xenobiotic metabolism in the target biological tissue and a surrogate biological tissue. The contrast data includes differences between activity measures of measurable nodes obtained from the surrogate biological tissue while exposed to the agent, and while exposed to a control. To determine the set of scores, a set of values is computed that indicates a perturbation of the surrogate biological tissue caused by the agent. A correlation is identified between the set of values for the backbone nodes obtained from the surrogate biological tissue and the set of scores that is indicative of a perturbation of the target biological tissue.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.