Carboxylic diarylthiazepineamines as mu-opioid receptor agonists

US10844027B2 · kind B2 · utility

Assignee

• The Trustees of Columbia University in the City of New York · US

Inventors

• Andrew Carry Kruegel · New York, US
• Dalibor Sames · New York, US
• Madalee G. Wulf · Ipswich, US
• Jonathan A. Javitch · Dobbs Ferry, US

Key dates

• Filing date: Sep 16, 2016
• Grant date: Nov 24, 2020
• Expiry date: Sep 16, 2036

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K2300/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides a compound having the structure of the instant invention of a pharmaceutically acceptable salt or ester thereof, methods of preparing the same, and methods of treating a subject with compounds of the instant invention in combination therapies.