Patent · US Active

Bone-targeting antibodies

US10844115B2 · kind B2 · utility

2Cited by

16References

6Claims

0Family size

Assignee

Genzyme Corporation · US

Inventors

Huawei Qiu · Westborough, US
Sunghae Park · Bound Brook, US
James Stefano · Bound Brook, US

Key dates

Filing date	Jan 19, 2018
Grant date	Nov 24, 2020
Priority date	—
Expiry date	Jan 19, 2038

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2319/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Provided are recombinant and chemically-conjugated antibodies and fragments thereof modified with one or more poly-aspartate (poly-D) peptides (e.g., a D10 sequence) to improve localization of the antibodies or fragments to bone. Methods of making and using of these antibodies and fragments also are disclosed.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.