Use of anti-pacap antibodies and antigen binding fragments thereof for treatment, prevention, or inhibition of photophobia

US10844116B2 · kind B2 · utility

Assignees

• University of Iowa Research Foundation · US
• H. LUNDBECK A/S · DK

Inventors

• Adisa Kuburas · North Liberty, US
• Ethan W. Ojala · Snohomish, US
• Pei Fan · Bothell, US
• Jeffrey T. L. Smith · Dublin, IE
• John Latham · Seattle, US
• Charlie Karasek · Seattle, US
• Jenny Mulligan · Lake Forest Park, US
• Michelle Scalley-Kim · Seattle, US
• Erica Stewart · Seattle, US
• Vanessa Lisbeth Rubin · Seattle, US
• Jens J. Billgren · Seattle, US
• Bianca Mason · Iowa City, US
• Levi P. Sowers · Iowa City, US
• Andrew F. Russo · Iowa City, US
• Maria-Cristina Loomis · Bothell, US
• Leon F. Garcia-Martinez · Woodinville, US
• Benjamin H. Dutzar · Seattle, US
• Daniel S. Allison · Lake Forest Park, US
• Katherine Lee Hendrix · Bothell, US

Key dates

• Filing date: Apr 15, 2016
• Grant date: Nov 24, 2020
• Expiry date: Apr 15, 2036

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention relates to methods of screening for anti-PACAP antibodies, or anti-PACAP receptor antibodies, and antigen binding fragments thereof, for potential use in treating or preventing PACAP-associated photophobia or light aversion, and therapeutic compositions containing and methods of using anti-PACAP antibodies, or anti-PACAP receptor antibodies, and antigen binding fragments thereof.