Structurally-enhanced miRNA inhibitor S-TuD
US10844376B2 · kind B2 · utility
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18Claims
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Key dates
| Filing date | Sep 16, 2016 |
| Grant date | Nov 24, 2020 |
| Priority date | — |
| Expiry date | Nov 9, 2036 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2310/53
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention pertains to the improvement of a miRNA inhibitor (a synthesized Tough Decoy (S-TuD)). The present invention provides a miRNA inhibitory complex including RNA or an analog thereof, wherein the RNA inhibitory complex includes at least one double-stranded structure and a miRNA binding sequence, each of two strands of the miRNA binding sequence being bound to two strands of at least one end of the double-stranded structure, and the miRNA inhibitory complex further includes at least one crosslinked nucleic acid.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.