Patent · US Active

Two-tailed self-delivering siRNA

US10844377B2 · kind B2 · utility

13Cited by

3References

30Claims

0Family size

Assignee

University of Massachusetts · US

Inventors

Anastasia Khvorova · Boulder, US
Julia Alterman · Worcester, US
Matthew Hassler · Worcester, US

Key dates

Filing date	Jun 22, 2018
Grant date	Nov 24, 2020
Priority date	—
Expiry date	Jul 11, 2038

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2310/346
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

Provided are compositions and methods comprising two-tailed siRNAs (tt-siRNAs) that exhibit unprecedented cellular uptake and silencing. Also provided are methods of treating neurological and other diseases with the two-tailed siRNAs of the invention.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.