Manganese supplementation for control of glycosylation in mammalian cell culture process
US10844416B2 · kind B2 · utility
2Cited by
2References
21Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jun 1, 2016 |
| Grant date | Nov 24, 2020 |
| Priority date | — |
| Expiry date | Jun 1, 2036 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2511/00
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention pertains to a cell culture medium comprising manganese as a media supplement, which was shown to control recombinant protein glycosylation and methods of using thereof. The present invention further pertains to a method of controlling or manipulating glycosylation of a recombinant protein of interest in a large scale cell culture.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.