Biosensor device to target analytes in situ, in vivo, and/or in real time, and methods of making and using the same

US10849540B2 · kind B2 · utility

Assignee

• The University of Toledo · US

Inventors

• Anand K. Agarwal · Ottawa Hills, US
• Vijay K. Goel · Toledo, US
• Dong-Shik Kim · Sylvania, US
• Do Young Yoon · Seoul, KR
• Boren Lin · Toledo, US
• Hamid Feyzizarnagh · Toledo, US

Key dates

• Filing date: Mar 11, 2014
• Grant date: Dec 1, 2020
• Expiry date: Jul 2, 2036

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

A biosensor device for the real-time detection of a target analyte includes a receptor component operatively connected to a transducer component which is adapted to interpret and transmit a detectable signal. The receptor component includes a sensing element capable of detecting and binding to at least one target analyte, and a self-assembled monolayer (SAM) layer. The SAM layer is positioned between and in contact with the sensing element and an electrode such that the sensing element, in the presence of the target analyte, causes a detectable signal capable of being transmitted to the electrode. The transducer component includes the electrode and microprocessor configured to screen noise and to pick up impedance change at a very low frequency range.