Multivalent vaccines for rabies virus and filoviruses

US10849975B2 · kind B2 · utility

Assignees

• Thomas Jefferson University · US
• The United States of America, as Represented by the Secretary, Department of Health and Human Services Services · US

Inventors

• Joseph E. Blaney · Frederick, US
• Jason Paragas · Bethesda, US
• Peter Jahrling · Middletown, US
• Reed F. Johnson · Frederick, US
• Matthias Schnell · Harleysville, US

Key dates

• Filing date: Feb 2, 2012
• Grant date: Dec 1, 2020
• Expiry date: Aug 1, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2760/20143
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides methods and compositions for inducing an immune response that confers dual protection against infections by either or both of a rabies virus and a filovirus, and/or which can be used therapeutically for an existing infection with rabies virus and/or a filovirus to treat at least one symptom thereof and/or to neutralize or clear the infecting agents. In particular, the present invention provides a recombinant rabies virus vector comprising a nucleotide sequence encoding at least one filovirus glycoprotein or an immunogenic fragment thereof, as well as pharmaceutical compositions comprising the vaccine vectors.