Methods for treating Parkinson's disease
US10849990B2 · kind B2 · utility
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6Claims
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Key dates
| Filing date | Apr 25, 2018 |
| Grant date | Dec 1, 2020 |
| Priority date | — |
| Expiry date | May 29, 2038 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2750/14143
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to a method for treating Parkinson's disease. According to this method, a halorhodopsin protein, a polynucleotide encoding the halorhodopsin protein or a vector containing the polynucleotide above is introduced into ventrolateral thalamus (VL) or medial globus pallidus (GPm) neurons of a subject having Parkinson's disease. The VL neurons are then illuminated with green light or exposed to a T type Ca2+ channel blocker to inhibit rebound firing of VL neurons. By inhibiting rebound firing of VL neurons, Parkinson's disease can be treated or prevented.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.