Processes and intermediates for NEP inhibitor synthesis

US10851059B2 · kind B2 · utility

Assignee

• Novartis AG · CH

Inventors

• Florian Karl Kleinbeck-Riniker · Basel, CH
• Ives Mafli · Zürich, CH
• Benjamin Martin · Clermont-Ferrand, FR
• Gerhard Penn · Oberwil, CH
• Gottfried Sedelmeier · Schallstadt, DE
• Joerg Matthias Sedelmeier · Weil am Rhein, DE
• Francesco VENTURONI · Basel, CH

Key dates

• Filing date: Aug 16, 2017
• Grant date: Dec 1, 2020
• Expiry date: Oct 11, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D207/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to a new chemical synthesis, intermediates and catalysts useful for the preparation of the neprilysin (NEP) inhibitor sacubitril, inter alia via nitro 5 compounds. It further relates to new intermediate compounds and their use for said new chemical synthesis route, as well as a new catalyst ligand.