GLP-1 receptor agonists and uses thereof

US10851081B2 · kind B2 · utility

Assignee

• PFIZER INC. · US

Inventors

• Gary Erik Aspnes · Biberach an der Riß, DE
• Scott W. Bagley · Voluntown, US
• John M. Curto · Mystic, US
• Matthew S. Dowling · Old Lyme, US
• David James Edmonds · Arlington, US
• Mark E. Flanagan · Gales Ferry, US
• Kentaro Futatsugi · Sharon, US
• David A. Griffith · Sudbury, US
• Kim Huard · Berkeley, US
• Gajendra Ingle · Groton, US
• Wenhua Jiao · Salem, US
• Chris Limberakis · Pawcatuck, US
• Alan M. Mathiowetz · Waltham, US
• David W. Piotrowski · Waterford, US
• Roger B. Ruggeri · Waterford, US

Key dates

• Filing date: Apr 29, 2020
• Grant date: Dec 1, 2020
• Expiry date: Apr 29, 2040

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided herein are 6-carboxylic acids of benzimidazoles and 4-aza-, 5-aza-, 7-aza- and 4,7-diaza-benzimidazoles as GLP-1R agonists, processes to make said compounds, and methods comprising administering said compounds to a mammal in need thereof.