Optimized microbial cells for production of melatonin and other compounds
US10851365B2 · kind B2 · utility
1Cited by
1References
21Claims
0Family size
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Key dates
| Filing date | Mar 30, 2017 |
| Grant date | Dec 1, 2020 |
| Priority date | — |
| Expiry date | Mar 30, 2037 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y402/01096
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Described herein are recombinant microbial host cells comprising biosynthetic pathways and their use in producing oxidation products and downstream products, e.g., melatonin and related compounds, as well as enzyme variants, nucleic acids, vectors and methods useful for preparing and using such cells. In specific aspects, the present invention relates to monooxygenases, e.g., amino acid hydroxylases, with a modified cofactor-dependency, and to enzyme variants and microbial cells providing for an improved supply of cofactors.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.