Patent · US Active

Method for in vitro detection and monitoring of a disease by measuring disease-associated protease activity in extracellular vesicles

US10851402B2 · kind B2 · utility

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2Claims

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Assignee

FRIEDRICH-ALEXANDER-UNIVERSITÄT ERLANGEN-NÜRNBERG · DE

Inventors

Andreas Baur · Erlangen, DE
Kalle Saksela · Espoo, FI
Gerold Schuler · Spardorf, DE

Key dates

Filing date	Jan 9, 2014
Grant date	Dec 1, 2020
Priority date	—
Expiry date	Jan 9, 2034

Classification

Technology area (CPC G)Physics
CPC primaryG01N2333/96494
WIPO fieldMeasurement
WIPO sectorInstruments

Abstract

The present invention relates to a method for in vitro detection and/or monitoring of a disease in a sample, based on measurement of enzymatic activity of proteases activated and secreted upon disease development, to modified peptides used for the enzymatic detection of the proteases, the use of the peptides, a kit comprising such peptides and the use of ADAM-protease activity as a surrogate marker for disease burden and activity in infectious, inflammatory, and malignant diseases, such as HIV infection and melanoma.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.