Left-handed gamma-peptide nucleic acids, methods of synthesis and uses therefor
US10851407B2 · kind B2 · utility
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4References
16Claims
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Key dates
| Filing date | May 8, 2015 |
| Grant date | Dec 1, 2020 |
| Priority date | — |
| Expiry date | Jan 20, 2037 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q1/6858
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A method of making optically pure preparations of chiral γPNA (gamma peptide nucleic acid) monomers is provided. Nano structures comprising chiral γPNA structures also are provided. Methods of amplifying and detecting specific nucleic acids, including in situ methods are provided as well as compositions and kits useful in those methods. Lastly, methods of converting nucleobase sequences from right-handed helical PNA, nucleic acid and nucleic acid analog structures to left-handed γPNA, and vice-versa, are provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.