Gas-phase purification for accurate isobaric tag-based quantification
US10852306B2 · kind B2 · utility
4Cited by
3References
7Claims
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Key dates
| Filing date | Jun 1, 2017 |
| Grant date | Dec 1, 2020 |
| Priority date | — |
| Expiry date | Jul 1, 2037 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T436/24
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Described herein are mass spectrometry systems and methods which improve the accuracy of isobaric tag-based quantification by alleviating the pervasive problem of precursor interference and co-isolation of impurities through gas-phase purification. During the gas-phase purification, the mass-to-charge ratios of precursor ions within at least a selected range are selectively changed allowing ions having similar unmodified mass-to-charge ratios to be separated before further isolation, fragmentation or analysis.
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