Method for optimizing the predetermination of the time profile of a contrast agent concentration in diagnostic imaging using a magnetic resonance system

US10852378B2 · kind B2 · utility

Assignee

• Bayer Pharma Aktiengesellschaft · DE

Inventors

• Martin Rohrer · Berlin, DE
• Gregor Jost · Berlin, DE
• Hubertus Pietsch · Kleinmachnow, DE
• Claus-Peter Reisinger · Wixom, US
• Harald Kramer · Planegg, DE

Key dates

• Filing date: May 10, 2016
• Grant date: Dec 1, 2020
• Expiry date: Aug 29, 2037

Classification

• Technology area (CPC G): Physics
• CPC primary: G01R33/5635
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

A method of predetermining the time profile of a contrast agent concentration at a vessel position is provided in the context of contrast agent-enhanced MRI of a region of interest only during the initial flooding-in phase of the contrast agent into the vessel situated in the region of interest. The method includes establishing a broadening of a contrast agent bolus profile according to the equation ΔW=W2−W1 wherein W1 is a first width of the contrast agent bolus profile at a first vessel position and W2 is a second width of a contrast agent concentration profile at a second vessel position within the region of interest. The broadening is established by determining at least one flow parameter which is dependent on at least one blood flow property of the patient at a third vessel position thereof and which correlates with the broadening of the contrast agent profile.