Nuclear imaging and radiotherapeutics agents targeting carbonic anhydrase IX and uses thereof

US10857246B2 · kind B2 · utility

Assignee

• THE JOHNS HOPKINS UNIVERSITY · US

Inventors

• Xing Yang · Baltimore, US
• Il Minn · Ellicott City, US
• Steven Rowe · Burkville, US
• Sangeeta Ray · Ellicott City, US
• Ronnie C. Mease · Fairfax, US
• Michael Gorin · Rockville, US
• Mohamad Allaf · Baltimore, US
• Martin G. Pomper · Baltimore, US

Key dates

• Filing date: Jun 1, 2016
• Grant date: Dec 8, 2020
• Expiry date: Jun 1, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Highly potent and selective radionuclide-based imaging and therapy agents targeting carbonic anhydrase IX with minimum non-specific organ uptake are disclosed. Methods of imaging and/or treating carbonic anhydrase IX-expressing cells or tumors also are disclosed.