Use of excess carbodiimide for peptide synthesis at elevated temperatures
US10858390B2 · kind B2 · utility
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Key dates
| Filing date | Aug 25, 2017 |
| Grant date | Dec 8, 2020 |
| Priority date | — |
| Expiry date | Aug 25, 2037 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K1/10
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
An improved method of coupling amino acids into peptides or peptidomimetics is disclosed in which the activation and coupling are carried out in the same vessel, in the presence of a carbodiimide in an amount greater than 1 equivalent as compared to the amino acid, in the presence of an activator additive, and at a temperature greater than 30° C.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.