Peptide mimotopes of claudin 18.2 and uses thereof

US10858415B2 · kind B2 · utility

Assignees

• TRON—Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg-Universität Mainz · DE
• JPT Peptide Technologies GmbH · DE
• BIONTECH SE · DE

Inventors

• Ugur Sahin · Mainz, DE
• Matin Daneschdar · Budenheim, DE
• Hans-Ulrich Schmoldt · Darmstadt, DE
• Laura-Marie Kring (née Plum) · Mainz, DE
• Markus Fiedler · Bodenwerder, DE
• Ulf Reimer · Berlin, DE
• Karsten Schnatbaum · Berlin, DE

Key dates

• Filing date: Jan 29, 2014
• Grant date: Dec 8, 2020
• Expiry date: Apr 10, 2037

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2500/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides molecules that mimic antigenic determinants of the integral transmembrane protein claudin 18.2 (CLDN18.2). These molecules compete with CLDN18.2 for binding to a CLDN18.2 binding domain, e.g. a CLDN18.2 binding domain of an antibody, and are capable of detecting antibodies against CLDN18.2. The mimotopes of the invention may be used to generate or inhibit immune responses in animals and preferably humans. Furthermore, they can be used for purposes of detecting agents comprising a CLDN18.2 binding domain in biological samples as well as for purifying agents comprising a CLDN18.2 binding domain.