Anti-PCSK9 antibodies and uses thereof

US10858446B2 · kind B2 · utility

Assignee

• PHARMAEXPLORER LIMITED · VG

Inventors

• Lile LIU · Shanghai, CN
• Jing Gao · 安丰镇, CN
• Xinxiu YANG · Shanghai, CN
• Zhiqiang Xu · Beijing, CN
• Shaoping HU · Shanghai, CN
• Lini HUANG · Shanghai, CN
• Hongzhuan GU · Shanghai, CN
• Yu Zhang · Shanghai, CN
• Yangyang Zhai · Shanghai, CN
• Tatchi Teddy YANG · Shanghai, CN

Key dates

• Filing date: Oct 14, 2016
• Grant date: Dec 8, 2020
• Expiry date: Sep 2, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/94
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Anti-PCSK9 antibodies and antigen-binding fragments thereof are described. Also described are nucleic acids encoding the antibodies, compositions comprising the antibodies, and methods of producing the antibodies and using the antibodies for treating or preventing diseases such as lipid disorders, metabolic diseases, hypercholesterolemia, inflammatory diseases and infectious diseases.